In T-cell acute lymphoblastic leukemia (T-ALL), more than 50% of cases display autoactivation of Notch1 signaling, leading to oncogenic transformation. We have previously identified a specific chemovar of Cannabis that induces apoptosis by preventing Notch1 m…

Targeting Notch signaling components has generated much interest for its therapeutic potential. However, so far efforts to develop treatments that target Notch signaling have been unsuccessful (Previ…