Dose-dependent effects of oral cannabidiol and delta-9-tetrahydrocannabinol on serum anandamide and related N-acylethanolamines in healthy volunteers
Background The mental health benefits of cannabidiol (CBD) are promising but can be inconsistent, in part due to challenges in defining an individual’s effective dosage. In schizophrenia, alterations in anandamide (AEA) concentrations, an endocannabinoid (eCB…
Methods
Human serum (n=75) was collected from two of our previous phase I clinical trials, exploring clinical and fMRI responses to CBD and 9-THC administration in HVs (LOGIN-TS4, GermanCTR: DRKS000…